Medicare Part D drugs (A–Z)
This is the index of the 350 highest-spend Medicare Part D drugs, out of about 3,598 drugs in the CMS dataset (data year 2023). Each has its own page with total spending, spending per dosage unit, per claim and per beneficiary, claims, beneficiaries, manufacturer and year-over-year change. The biggest is Eliquis (Apixaban) at $18,273,451,967. Use the top-50 table or jump to a letter below. These are aggregate program figures, not the price you pay.
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
Top 50 drugs by total Part D spending (2023)
| Rank | Drug | Total spend | Per dosage unit | Beneficiaries |
|---|---|---|---|---|
| #1 | Eliquis (Apixaban) | $18,273,451,967 | $9.74 | 3,927,848 |
| #2 | Ozempic (Semaglutide) | $9,194,048,435 | $355.90 | 1,464,468 |
| #3 | Jardiance (Empagliflozin) | $8,839,935,063 | $20.32 | 1,882,768 |
| #4 | Trulicity (Dulaglutide) | $7,363,856,224 | $483.21 | 938,731 |
| #5 | Xarelto (Rivaroxaban) | $6,309,246,823 | $18.23 | 1,324,165 |
| #6 | Trelegy Ellipta (Fluticasone/Umeclidin/Vilanter) | $4,455,884,010 | $11.18 | 1,050,583 |
| #7 | Humira(Cf) Pen (Adalimumab) | $4,419,828,188 | $3,750.06 | 61,474 |
| #8 | Farxiga (Dapagliflozin Propanediol) | $4,342,182,307 | $19.55 | 993,909 |
| #9 | Januvia (Sitagliptin Phosphate) | $4,090,836,821 | $18.88 | 843,391 |
| #10 | Revlimid (Lenalidomide) | $3,859,804,789 | $878.21 | 36,967 |
| #11 | Entresto (Sacubitril/Valsartan) | $3,430,441,590 | $11.64 | 663,587 |
| #12 | Lantus Solostar (Insulin Glargine,Hum.Rec.Anlog) | $3,157,233,282 | $30.28 | 1,198,294 |
| #13 | Biktarvy (Bictegrav/Emtricit/Tenofov Ala) | $3,152,256,269 | $133.13 | 83,843 |
| #14 | Stelara* (Ustekinumab) | $2,987,778,600 | $26,818.03 | 22,930 |
| #15 | Xtandi (Enzalutamide) | $2,601,510,278 | $146.13 | 28,658 |
| #16 | Myrbetriq (Mirabegron) | $2,510,288,600 | $15.43 | 769,978 |
| #17 | Imbruvica (Ibrutinib) | $2,371,893,292 | $486.63 | 17,100 |
| #18 | Mounjaro (Tirzepatide) | $2,361,384,157 | $539.82 | 370,203 |
| #19 | Enbrel Sureclick (Etanercept) | $2,054,858,499 | $1,812.36 | 34,287 |
| #20 | Ibrance (Palbociclib) | $2,020,903,604 | $753.02 | 16,015 |
| #21 | Symbicort (Budesonide/Formoterol Fumarate) | $2,004,295,918 | $38.98 | 984,400 |
| #22 | Jakafi (Ruxolitinib Phosphate) | $1,940,765,069 | $297.88 | 14,041 |
| #23 | Novolog Flexpen (Insulin Aspart) | $1,875,605,627 | $38.82 | 588,526 |
| #24 | Ofev (Nintedanib Esylate) | $1,837,061,150 | $220.84 | 20,444 |
| #25 | Linzess (Linaclotide) | $1,825,245,843 | $18.14 | 565,088 |
| #26 | Invega Sustenna (Paliperidone Palmitate) | $1,821,418,393 | $2,343.53 | 70,988 |
| #27 | Pomalyst (Pomalidomide) | $1,709,288,465 | $1,088.76 | 12,739 |
| #28 | Ingrezza (Valbenazine Tosylate) | $1,705,132,723 | $267.57 | 29,191 |
| #29 | Lenalidomide | $1,681,292,157 | $682.29 | 20,403 |
| #30 | Rybelsus (Semaglutide) | $1,665,906,943 | $32.41 | 285,693 |
| #31 | Restasis (Cyclosporine) | $1,501,664,198 | $11.33 | 492,479 |
| #32 | Creon (Lipase/Protease/Amylase) | $1,466,866,603 | $8.87 | 185,325 |
| #33 | Arexvy (Rsvpref3 Antigen/As01e/PF) | $1,387,933,256 | $315.81 | 4,390,151 |
| #34 | Breo Ellipta (Fluticasone/Vilanterol) | $1,373,600,714 | $6.94 | 556,799 |
| #35 | Vyndamax (Tafamidis) | $1,349,659,508 | $735.47 | 7,589 |
| #36 | Tradjenta (Linagliptin) | $1,293,567,778 | $18.04 | 286,808 |
| #37 | Calquence (Acalabrutinib Maleate) | $1,286,819,830 | $255.96 | 12,390 |
| #38 | Tagrisso (Osimertinib Mesylate) | $1,231,962,204 | $569.45 | 9,387 |
| #39 | Shingrix (Varicella-Zoster Ge/As01b/PF) | $1,211,171,028 | $212.26 | 3,894,337 |
| #40 | Humalog Kwikpen U-100 (Insulin Lispro) | $1,208,385,334 | $35.80 | 418,431 |
| #41 | Skyrizi Pen (Risankizumab-Rzaa) | $1,189,321,833 | $20,593.60 | 18,206 |
| #42 | Austedo (Deutetrabenazine) | $1,123,439,045 | $103.61 | 18,283 |
| #43 | Cabometyx (Cabozantinib S-Malate) | $1,109,315,042 | $878.24 | 8,210 |
| #44 | Repatha Sureclick (Evolocumab) | $1,092,210,722 | $286.44 | 229,666 |
| #45 | Xifaxan (Rifaximin) | $1,090,110,101 | $54.93 | 96,011 |
| #46 | Dupixent Pen (Dupilumab) | $1,081,417,351 | $951.72 | 41,263 |
| #47 | Erleada (Apalutamide) | $1,057,789,083 | $156.58 | 11,077 |
| #48 | Tresiba Flextouch U-200 (Insulin Degludec) | $1,047,670,731 | $71.71 | 197,096 |
| #49 | Levemir Flexpen (Insulin Detemir) | $1,025,556,477 | $32.59 | 346,204 |
| #50 | Opsumit (Macitentan) | $1,018,837,123 | $424.66 | 9,031 |
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
All 350 drugs A–Z
Jump to: A B C D E F G H I J K L M N O P Q R S T U V W X Z
A
- Abilify Maintena (Aripiprazole) · $636,857,891
- Abiraterone Acetate · $877,469,517
- Abrysvo (Rsv Vacc, Pref A And Pref B/PF) · $698,160,178
- Actemra Actpen (Tocilizumab) · $184,648,416
- Actemra* (Tocilizumab) · $135,711,700
- Acthar (Corticotropin) · $377,839,859
- Adempas (Riociguat) · $598,223,220
- Advair Diskus (Fluticasone Propion/Salmeterol) · $868,795,720
- Advair HFA (Fluticasone Propion/Salmeterol) · $398,376,288
- Aimovig Autoinjector (Erenumab-Aooe) · $326,938,686
- Albuterol Sulfate HFA (Albuterol Sulfate) · $583,910,454
- Alecensa (Alectinib HCl) · $185,955,638
- Allopurinol · $136,919,933
- Alphagan P (Brimonidine Tartrate) · $181,159,172
- Ambrisentan · $246,059,319
- Amlodipine Besylate · $407,233,375
- Anoro Ellipta (Umeclidinium Brm/Vilanterol Tr) · $872,959,570
- Aptiom (Eslicarbazepine Acetate) · $142,014,028
- Arexvy (Rsvpref3 Antigen/As01e/PF) · $1,387,933,256
- Arikayce (Amikacin Liposomal/Neb.Accessr) · $161,637,429
- Aripiprazole · $372,728,723
- Aristada (Aripiprazole Lauroxil) · $272,878,291
- Atorvastatin Calcium · $1,000,689,622
- Atrovent HFA (Ipratropium Bromide) · $131,864,275
- Aubagio (Teriflunomide) · $353,934,133
- Auryxia (Ferric Citrate) · $182,627,699
- Austedo (Deutetrabenazine) · $1,123,439,045
- Avonex (Interferon Beta-1a) · $139,326,335
- Avonex Pen (Interferon Beta-1a) · $178,045,109
B
- Basaglar Kwikpen U-100 (Insulin Glargine,Hum.Rec.Anlog) · $647,548,319
- Belbuca (Buprenorphine HCl) · $149,974,661
- Belsomra (Suvorexant) · $161,202,978
- Benlysta* (Belimumab) · $187,011,628
- Biktarvy (Bictegrav/Emtricit/Tenofov Ala) · $3,152,256,269
- Bosulif (Bosutinib) · $199,137,491
- Breo Ellipta (Fluticasone/Vilanterol) · $1,373,600,714
- Breztri Aerosphere (Budesonide/Glycopyr/Formoterol) · $795,861,627
- Brilinta (Ticagrelor) · $691,725,954
- Briviact* (Brivaracetam) · $184,375,922
- Brukinsa (Zanubrutinib) · $801,426,531
- Budesonide-Formoterol Fumarate (Budesonide/Formoterol Fumarate) · $140,028,972
- Buprenorphine · $119,900,450
- Buprenorphine-Naloxone (Buprenorphine HCl/Naloxone HCl) · $231,087,289
- Bupropion XL (Bupropion HCl) · $197,171,943
- Buspirone HCl · $134,026,927
- Bydureon Bcise (Exenatide Microspheres) · $284,056,759
C
- Cabenuva (Cabotegravir/Rilpivirine) · $165,605,768
- Cabometyx (Cabozantinib S-Malate) · $1,109,315,042
- Calquence (Acalabrutinib Maleate) · $1,286,819,830
- Caplyta (Lumateperone Tosylate) · $194,921,427
- Carbidopa-Levodopa (Carbidopa/Levodopa) · $125,111,276
- Carvedilol · $178,694,094
- Celecoxib · $198,046,988
- Cimzia (Certolizumab PEGol) · $275,055,734
- Cinacalcet HCl · $127,786,945
- Clobetasol Propionate · $152,266,243
- Clopidogrel (Clopidogrel Bisulfate) · $201,696,339
- Combigan (Brimonidine Tartrate/Timolol) · $232,102,953
- Combivent Respimat (Ipratropium/Albuterol Sulfate) · $456,397,647
- Copaxone (Glatiramer Acetate) · $369,370,974
- Cosentyx Sensoready (2 Pens) (Secukinumab) · $852,693,125
- Cosentyx Sensoready Pen (Secukinumab) · $205,397,019
- Creon (Lipase/Protease/Amylase) · $1,466,866,603
- Cyclosporine* (Cyclosporine) · $255,901,494
D
- Daptomycin · $132,869,162
- Descovy (Emtricitabine/Tenofov Alafenam) · $589,840,789
- Dexlansoprazole Dr (Dexlansoprazole) · $315,328,215
- Diclofenac Sodium* (Diclofenac Sodium) · $396,080,706
- Dificid (Fidaxomicin) · $127,162,103
- Diltiazem 24hr ER (Cd) (Diltiazem HCl) · $157,172,185
- Divalproex Sodium · $141,849,481
- Divalproex Sodium ER (Divalproex Sodium) · $120,375,972
- Donepezil HCl · $119,677,286
- Dovato (Dolutegravir Sodium/Lamivudine) · $433,449,386
- Doxycycline Hyclate* (Doxycycline Hyclate) · $117,340,524
- Duloxetine HCl · $398,813,266
- Dupixent Pen (Dupilumab) · $1,081,417,351
- Dupixent Syringe (Dupilumab) · $633,292,043
E
- Eliquis (Apixaban) · $18,273,451,967
- Emgality Pen (Galcanezumab-Gnlm) · $229,252,597
- Enbrel (Etanercept) · $627,419,987
- Enbrel Mini (Etanercept) · $269,006,301
- Enbrel Sureclick (Etanercept) · $2,054,858,499
- Entresto (Sacubitril/Valsartan) · $3,430,441,590
- Epclusa (Sofosbuvir/Velpatasvir) · $877,398,115
- Epidiolex (Cannabidiol (Cbd)) · $197,357,912
- Epinephrine · $133,365,359
- Erleada (Apalutamide) · $1,057,789,083
- Escitalopram Oxalate · $171,914,954
- Esomeprazole Magnesium · $172,016,821
- Estradiol* (Estradiol) · $239,154,624
- Everolimus · $240,732,669
- Evrysdi (Risdiplam) · $132,416,369
- Ezetimibe · $290,177,168
F
- Famotidine* (Famotidine) · $202,810,000
- Farxiga (Dapagliflozin Propanediol) · $4,342,182,307
- Fasenra Pen (Benralizumab) · $172,931,998
- Firdapse (Amifampridine Phosphate) · $146,333,212
- Flovent HFA (Fluticasone Propionate) · $394,517,813
- Fluticasone Propionate* (Fluticasone Propionate) · $201,536,224
- Fluticasone-Salmeterol (Fluticasone Propion/Salmeterol) · $414,349,616
- Forteo (Teriparatide) · $425,012,975
- Furosemide* (Furosemide) · $144,867,532
G
- Gabapentin · $655,916,853
- Gammagard Liquid (Immun Glob G(IgG)/Gly/IgA Ov50) · $542,812,337
- Gammaked (Immune Globul G/Gly/IgA Avg 46) · $220,007,929
- Gammaplex (Immun Glob G(IgG)/Gly/IgA 0-50) · $265,296,669
- Gamunex-C (Immune Globul G/Gly/IgA Avg 46) · $482,557,331
- Gattex (Teduglutide) · $330,401,875
- Gemtesa (Vibegron) · $508,474,527
- Genvoya (Elviteg/Cob/Emtri/Tenof Alafen) · $626,148,344
- Gilenya (Fingolimod HCl) · $125,490,483
- Glatiramer Acetate · $151,487,542
- Glyxambi (Empagliflozin/Linagliptin) · $136,590,648
H
- Hizentra (Immun Glob G(IgG)/Pro/IgA 0-50) · $176,244,902
- Humalog (Insulin Lispro) · $458,058,582
- Humalog Kwikpen U-100 (Insulin Lispro) · $1,208,385,334
- Humalog Kwikpen U-200 (Insulin Lispro) · $224,440,404
- Humalog Mix 75-25 Kwikpen (Insulin Lispro Protamin/Lispro) · $213,875,690
- Humira (Adalimumab) · $257,644,313
- Humira Pen (Adalimumab) · $835,162,056
- Humira(Cf) (Adalimumab) · $445,800,874
- Humira(Cf) Pen (Adalimumab) · $4,419,828,188
- Humulin 70/30 Kwikpen (Insulin NPh Hum/Reg Insulin Hm) · $124,346,168
- Humulin R U-500 Kwikpen (Insulin Regular, Human) · $263,635,305
- Hydrocodone-Acetaminophen (Hydrocodone/Acetaminophen) · $423,142,555
- Hydroxychloroquine Sulfate · $150,778,930
I
- Ibrance (Palbociclib) · $2,020,903,604
- Iclusig (Ponatinib HCl) · $123,338,680
- Icosapent Ethyl · $228,873,224
- Idhifa (Enasidenib Mesylate) · $118,905,343
- Imatinib Mesylate · $211,095,557
- Imbruvica (Ibrutinib) · $2,371,893,292
- Incruse Ellipta (Umeclidinium Bromide) · $456,391,929
- Ingrezza (Valbenazine Tosylate) · $1,705,132,723
- Inlyta (Axitinib) · $466,771,314
- Insulin Lispro Kwikpen U-100 (Insulin Lispro) · $129,467,811
- Invega Sustenna (Paliperidone Palmitate) · $1,821,418,393
- Invega Trinza (Paliperidone Palmitate) · $529,817,416
- Invokana (Canagliflozin) · $357,419,494
- Isentress (Raltegravir Potassium) · $130,537,595
J
- Jakafi (Ruxolitinib Phosphate) · $1,940,765,069
- Janumet (Sitagliptin Phos/Metformin HCl) · $798,865,849
- Janumet XR (Sitagliptin Phos/Metformin HCl) · $392,139,531
- Januvia (Sitagliptin Phosphate) · $4,090,836,821
- Jardiance (Empagliflozin) · $8,839,935,063
- Juluca (Dolutegravir/Rilpivirine) · $392,257,065
K
- Kerendia (Finerenone) · $269,681,549
- Kesimpta Pen (Ofatumumab) · $413,095,697
- Kisqali (Ribociclib Succinate) · $370,771,679
- Korlym (Mifepristone) · $228,814,734
- Krystexxa (PEGloticase) · $178,838,011
L
- Lacosamide* (Lacosamide) · $160,659,898
- Lantus (Insulin Glargine,Hum.Rec.Anlog) · $735,735,411
- Lantus Solostar (Insulin Glargine,Hum.Rec.Anlog) · $3,157,233,282
- Latanoprost · $215,961,787
- Latuda (Lurasidone HCl) · $455,172,742
- Lenalidomide · $1,681,292,157
- Lenvima (Lenvatinib Mesylate) · $778,834,824
- Levemir (Insulin Detemir) · $287,253,250
- Levemir Flexpen (Insulin Detemir) · $1,025,556,477
- Levemir Flextouch (Insulin Detemir) · $184,280,489
- Levetiracetam* (Levetiracetam) · $171,482,383
- Levothyroxine Sodium* (Levothyroxine Sodium) · $653,594,902
- Lidocaine · $179,454,361
- Linzess (Linaclotide) · $1,825,245,843
- Lisinopril · $331,855,070
- Livalo (Pitavastatin Calcium) · $189,914,605
- Lokelma (Sodium Zirconium Cyclosilicate) · $205,055,771
- Lonsurf (Trifluridine/Tipiracil HCl) · $176,155,837
- Losartan Potassium · $487,624,151
- Losartan-Hydrochlorothiazide (Losartan/Hydrochlorothiazide) · $118,183,005
- Lumakras (Sotorasib) · $140,234,716
- Lumigan (Bimatoprost) · $697,002,199
- Lupron Depot (Leuprolide Acetate) · $128,884,249
- Lurasidone HCl · $232,956,481
- Lynparza (Olaparib) · $487,431,793
M
- Mavenclad (Cladribine) · $156,344,544
- Mavyret (Glecaprevir/Pibrentasvir) · $232,993,526
- Mekinist (Trametinib Dimethyl Sulfoxide) · $173,398,802
- Memantine HCl · $207,922,964
- Mesalamine* (Mesalamine) · $271,604,425
- Metformin ER Gastric (Metformin HCl) · $191,118,411
- Metformin HCl · $247,531,906
- Metformin HCl ER (Metformin HCl) · $127,749,569
- Metoprolol Succinate · $587,676,864
- Metoprolol Tartrate* (Metoprolol Tartrate) · $140,066,633
- Mirtazapine · $176,432,051
- Montelukast Sodium · $190,742,362
- Mounjaro (Tirzepatide) · $2,361,384,157
- Movantik (Naloxegol Oxalate) · $140,596,853
- Multaq (Dronedarone HCl) · $409,348,468
- Myrbetriq (Mirabegron) · $2,510,288,600
N
- Nano 2nd Gen Pen Needle (Pen Needle, Diabetic) · $127,016,041
- Nifedipine ER (Nifedipine) · $146,639,465
- Ninlaro (Ixazomib Citrate) · $311,982,549
- Novolog (Insulin Aspart) · $518,394,273
- Novolog Flexpen (Insulin Aspart) · $1,875,605,627
- Novolog Mix 70-30 Flexpen (Insulin Aspart Prot/Insuln Asp) · $335,124,166
- Nubeqa (Darolutamide) · $576,350,299
- Nucala (Mepolizumab) · $260,986,344
- Nuedexta (Dextromethorphan HBr/Quinidine) · $180,648,015
- Nuplazid (Pimavanserin Tartrate) · $595,675,170
- Nurtec ODT (Rimegepant Sulfate) · $478,240,312
O
- Ocaliva (Obeticholic Acid) · $163,801,289
- Ocrevus (Ocrelizumab) · $157,049,386
- Octagam (Immun Globg(IgG)/Malt/IgA Ov50) · $300,823,932
- Odefsey (Emtricitab/Rilpiviri/Tenof Ala) · $383,667,795
- Ofev (Nintedanib Esylate) · $1,837,061,150
- Olanzapine* (Olanzapine) · $127,379,077
- Omeprazole · $422,372,715
- Omeprazole-Sodium Bicarbonate (Omeprazole/Sodium Bicarbonate) · $174,703,369
- Omnipod 5 G6 Pods (Gen 5) (Insulin Pump Cart,Automated,Bt) · $160,474,984
- Opsumit (Macitentan) · $1,018,837,123
- Orencia (Abatacept) · $178,400,675
- Orencia Clickject (Abatacept) · $451,311,111
- Orenitram ER (Treprostinil Diolamine) · $182,517,617
- Orgovyx (Relugolix) · $276,597,252
- Orserdu (Elacestrant HCl) · $127,626,022
- Otezla (Apremilast) · $876,955,030
- Oxervate (Cenegermin-Bkbj) · $493,161,481
- Oxycodone HCl · $151,932,933
- Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) · $263,023,627
- Oxycontin (Oxycodone HCl) · $390,573,654
- Ozempic (Semaglutide) · $9,194,048,435
P
- Paliperidone ER (Paliperidone) · $143,466,904
- Pantoprazole Sodium* (Pantoprazole Sodium) · $384,047,698
- Panzyga (Immun Glob G(IgG)-Ifas/Glycine) · $158,695,483
- Pennsaid (Diclofenac Sodium) · $134,792,075
- Piqray (Alpelisib) · $138,440,781
- Pirfenidone · $172,753,686
- Pomalyst (Pomalidomide) · $1,709,288,465
- Potassium Chloride* (Potassium Chloride) · $396,202,925
- Pradaxa (Dabigatran Etexilate Mesylate) · $176,220,137
- Praluent Pen (Alirocumab) · $475,918,669
- Pravastatin Sodium · $183,603,098
- Prednisolone Acetate · $163,897,057
- Pregabalin · $287,950,539
- Premarin* (Estrogens, Conjugated) · $279,329,987
- Prezcobix (Darunavir/Cobicistat) · $271,838,024
- Prezista (Darunavir) · $133,001,203
- Privigen (Immun Glob G(IgG)/Pro/IgA 0-50) · $381,709,147
- Procrit (Epoetin Alfa) · $163,098,995
- Prolastin C (Alpha-1-Proteinase Inhibitor) · $245,697,212
- Prolia (Denosumab) · $673,286,887
- Promacta (Eltrombopag Olamine) · $557,676,106
Q
- Quetiapine Fumarate · $201,087,913
- Qulipta (Atogepant) · $137,880,798
R
- Radicava Ors (Edaravone) · $293,678,844
- Ranolazine ER (Ranolazine) · $156,156,266
- Rebif (Interferon Beta-1a/Albumin) · $131,300,521
- Relistor* (Methylnaltrexone Bromide) · $132,882,335
- Relyvrio (Sod Phenylbutyrat/Taurursodiol) · $197,561,230
- Repatha Sureclick (Evolocumab) · $1,092,210,722
- Repatha Syringe (Evolocumab) · $128,112,297
- Restasis (Cyclosporine) · $1,501,664,198
- Revlimid (Lenalidomide) · $3,859,804,789
- Rexulti (Brexpiprazole) · $630,013,840
- Rezurock (Belumosudil Mesylate) · $146,107,630
- Rhopressa (Netarsudil Mesylate) · $174,888,744
- Rinvoq (Upadacitinib) · $976,330,771
- Risperdal Consta (Risperidone Microspheres) · $181,758,052
- Rocklatan (Netarsudil Mesylat/Latanoprost) · $146,478,267
- Rosuvastatin Calcium · $604,421,766
- Rybelsus (Semaglutide) · $1,665,906,943
- Rytary (Carbidopa/Levodopa) · $266,869,488
S
- Santyl (Collagenase Clostridium Hist.) · $194,978,096
- Sertraline HCl · $173,568,167
- Sevelamer Carbonate · $189,369,170
- Shingrix (Varicella-Zoster Ge/As01b/PF) · $1,211,171,028
- Simponi (Golimumab) · $177,180,473
- Simvastatin · $172,937,895
- Skyrizi On-Body (Risankizumab-Rzaa) · $125,306,777
- Skyrizi Pen (Risankizumab-Rzaa) · $1,189,321,833
- Skyrizi* (Risankizumab-Rzaa) · $289,245,101
- Soliqua 100-33 (Insulin Glargine/Lixisenatide) · $302,998,642
- Soliris (Eculizumab) · $223,473,529
- Spiriva Handihaler (Tiotropium Bromide) · $782,927,125
- Spiriva Respimat (Tiotropium Bromide) · $923,556,171
- Sprycel (Dasatinib) · $510,233,995
- Stelara* (Ustekinumab) · $2,987,778,600
- Stiolto Respimat (Tiotropium Br/Olodaterol HCl) · $432,253,137
- Strensiq (Asfotase Alfa) · $258,940,106
- Sucralfate · $160,271,432
- Symbicort (Budesonide/Formoterol Fumarate) · $2,004,295,918
- Symtuza (Darunavir/Cob/Emtri/Tenof Alaf) · $468,770,365
- Synjardy (Empagliflozin/Metformin HCl) · $163,646,663
- Synjardy XR (Empagliflozin/Metformin HCl) · $278,415,269
- Synthroid (Levothyroxine Sodium) · $355,295,646
T
- Tafinlar (Dabrafenib Mesylate) · $146,891,650
- Tagrisso (Osimertinib Mesylate) · $1,231,962,204
- Takhzyro (Lanadelumab-Flyo) · $194,367,297
- Taltz Autoinjector (Ixekizumab) · $474,538,369
- Tamsulosin HCl · $396,151,734
- Tasigna (Nilotinib HCl) · $394,675,625
- Tecfidera (Dimethyl Fumarate) · $234,518,996
- Tepezza (Teprotumumab-Trbw) · $129,065,494
- Tibsovo (IVosidenib) · $184,488,983
- Tivicay (Dolutegravir Sodium) · $657,133,269
- Toujeo Max Solostar (Insulin Glargine,Hum.Rec.Anlog) · $488,777,502
- Toujeo Solostar (Insulin Glargine,Hum.Rec.Anlog) · $541,871,908
- Tradjenta (Linagliptin) · $1,293,567,778
- Trazodone HCl · $216,388,379
- Trelegy Ellipta (Fluticasone/Umeclidin/Vilanter) · $4,455,884,010
- Tremfya (Guselkumab) · $531,497,098
- Tresiba Flextouch U-100 (Insulin Degludec) · $726,928,549
- Tresiba Flextouch U-200 (Insulin Degludec) · $1,047,670,731
- Trikafta (Elexacaftor/Tezacaftor/IVacaft) · $674,525,362
- Trintellix (Vortioxetine Hydrobromide) · $389,714,302
- Triumeq (Abacavir/Dolutegravir/Lamivudi) · $631,607,443
- Trulance (Plecanatide) · $119,272,260
- Trulicity (Dulaglutide) · $7,363,856,224
- Tymlos (Abaloparatide) · $197,623,448
- Tyvaso Dpi (Treprostinil) · $436,921,533
U
- Ubrelvy (Ubrogepant) · $314,663,943
- Ultomiris (Ravulizumab-Cwvz) · $159,533,070
- Uptravi (Selexipag) · $758,070,464
V
- Valacyclovir (Valacyclovir HCl) · $121,564,610
- Valsartan · $147,687,750
- Varenicline Tartrate · $189,563,599
- Vascepa (Icosapent Ethyl) · $763,988,447
- Velphoro (Sucroferric Oxyhydroxide) · $465,812,435
- Veltassa (Patiromer Calcium Sorbitex) · $153,775,939
- Vemlidy (Tenofovir Alafenamide) · $187,858,704
- Venclexta (Venetoclax) · $814,653,975
- Venlafaxine HCl ER (Venlafaxine HCl) · $151,208,248
- Ventolin HFA (Albuterol Sulfate) · $192,500,838
- Verzenio (Abemaciclib) · $756,850,867
- Victoza 2-Pak (Liraglutide) · $317,213,565
- Victoza 3-Pak (Liraglutide) · $1,004,635,145
- Vraylar (Cariprazine HCl) · $935,653,082
- Vumerity (Diroximel Fumarate) · $152,400,689
- Vyndamax (Tafamidis) · $1,349,659,508
- Vyndaqel (Tafamidis Meglumine) · $118,169,381
- Vyvanse (Lisdexamfetamine Dimesylate) · $138,990,768
- Vyvgart (Efgartigimod Alfa-Fcab) · $200,002,141
- Vyzulta (Latanoprostene Bunod) · $117,369,728
W
- Wixela Inhub (Fluticasone Propion/Salmeterol) · $272,994,335
X
- Xarelto (Rivaroxaban) · $6,309,246,823
- Xeljanz (Tofacitinib Citrate) · $279,993,121
- Xeljanz XR (Tofacitinib Citrate) · $585,772,572
- Xifaxan (Rifaximin) · $1,090,110,101
- Xigduo XR (Dapaglifloz Propaned/Metformin) · $198,894,543
- Xiidra (Lifitegrast) · $472,712,971
- Xolair (Omalizumab) · $254,056,609
- Xtampza ER (Oxycodone Myristate) · $250,042,795
- Xtandi (Enzalutamide) · $2,601,510,278
- Xywav (Sodium,Calcium,Mag,Pot Oxybate) · $168,733,996
Z
- Zejula (Niraparib Tosylate) · $161,500,239
- Zenpep (Lipase/Protease/Amylase) · $443,196,731
Frequently asked questions
How many drugs are in the Medicare Part D spending data?
The CMS Medicare Part D Spending by Drug dataset covers about 3,598 drugs for data year 2023. This site publishes a full detail page for the 350 highest-spend drugs (which account for the large majority of total program spending); the long tail of lower-spend drugs is listed in the ranking tables and will be expanded in later waves.
How are the drugs sorted?
The headline table is sorted by total Medicare Part D spending in 2023 (highest first). The A-Z index below lists every published drug alphabetically by brand name so you can jump straight to one.
More ways to explore
Data: CMS Medicare Part D Spending by Drug (data year 2023), U.S. public domain. Aggregate program spending, not the price you pay. Data as of June 2026.
Last updated: 2026-06-21