Estradiol* (Estradiol) — Medicare Part D spending
Multiple manufacturers (14) · Rank #196 by total Part D spend · CMS data year 2023
Medicare Part D spent $239,154,624 on Estradiol* (Estradiol) in 2023, the #196 drug by total Part D spending out of 3,598 drugs. That worked out to about $2.16 per dosage unit, $70 per claim and $185 per beneficiary, across 3,394,970 claims for 1,289,816 beneficiaries. Average spending per dosage unit fell -2.0% from 2022. These are aggregate Medicare program figures (gross drug cost), not the price you pay.
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
Estradiol* (Estradiol) spending at a glance (2023)
| Metric | Estradiol* (Estradiol) |
|---|---|
| Total Part D spending (2023) | $239,154,624 |
| Total spending (2022) | $220,162,983 |
| Year-over-year change in total spending | +8.6% |
| Average spending per dosage unit (2023) | $2.16 |
| Change in spend per dosage unit (YoY) | -2.0% |
| Avg annual change per dosage unit (2019-2023 CAGR) | -2.0% |
| Average spending per claim (2023) | $70 |
| Average spending per beneficiary (2023) | $185 |
| Total claims (2023) | 3,394,970 |
| Beneficiaries (2023) | 1,289,816 |
| Total dosage units (2023) | 184,892,356 |
| Manufacturer(s) | Multiple manufacturers (14) |
| National rank by total spend (of 3,598 drugs) | #196 |
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
2022 vs 2023
| Metric | 2022 | 2023 | Change |
|---|---|---|---|
| Total spending | $220,162,983 | $239,154,624 | +8.6% |
| Avg spend per dosage unit | $2.20 | $2.16 | -2.0% |
| Avg spend per claim | $71 | $70 | — |
| Avg spend per beneficiary | $194 | $185 | — |
| Total claims | 3,103,987 | 3,394,970 | — |
| Beneficiaries | 1,136,646 | 1,289,816 | — |
How Estradiol* compares with nearby drugs
Drugs with total Part D spending closest to Estradiol* (Estradiol):
| Drug (rank) | Total spend 2023 | Per dosage unit | Per-unit YoY |
|---|---|---|---|
| Estradiol* (Estradiol) (this drug, #196) | $239,154,624 | $2.16 | -2.0% |
| Prolastin C (Alpha-1-Proteinase Inhibitor) (#194) | $245,697,212 | $0.56 | +2.2% |
| Everolimus (#195) | $240,732,669 | $209.52 | -11.5% |
| Tecfidera (Dimethyl Fumarate) (#197) | $234,518,996 | $159.28 | +9.5% |
| Mavyret (Glecaprevir/Pibrentasvir) (#198) | $232,993,526 | $166.23 | +0.8% |
| Lurasidone HCl (#199) | $232,956,481 | $12.06 | — |
Frequently asked questions
How much does Medicare Part D spend on Estradiol*?
Medicare Part D spent $239,154,624 on Estradiol* (Estradiol) in 2023 (the latest CMS data year), across 3,394,970 claims for 1,289,816 beneficiaries. That ranks #196 of 3,598 drugs by total Part D spending. This is gross drug cost (Medicare, plan and beneficiary payments combined), not the price you personally pay.
What is the average spending per dosage unit for Estradiol*?
In 2023, the weighted average Medicare Part D spending per dosage unit for Estradiol* (Estradiol) was $2.16. Compared with 2022 it fell -2.0%. A "dosage unit" is one pill, tablet, milliliter or other billing unit, so this is not the price of a prescription.
Who makes Estradiol*?
CMS attributes Estradiol* (Estradiol) to Multiple manufacturers (14) in the 2023 Part D spending file. Average spending per claim was $70 and per beneficiary $185.
Is the Estradiol* figure the price I pay?
No. These are aggregate Medicare Part D program figures (total gross drug cost and averages across all claims), published by CMS for transparency. Your out-of-pocket cost depends on your plan, formulary, deductible and coverage phase. Always check your plan and talk to your pharmacist or doctor.
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Source & what this means
Figures are from the CMS Medicare Part D Spending by Drug dataset (data year 2023, US public domain). "Total spending" is the gross drug cost — Medicare, plan and beneficiary payments combined — for Part D claims; it is not a list price, a negotiated price, or what any individual pays. Spending per dosage unit is volume-weighted across formulations. This is general public-spending information, not medical or pricing advice. Your own cost depends on your plan, deductible and coverage phase — verify with your Part D plan and a pharmacist. Data as of June 2026. See our methodology and disclaimer.
Last updated: 2026-06-20