Medicare Part D drug rankings
These rankings sort the 3,598 drugs in the CMS Medicare Part D dataset (2023) by the questions people search most: the biggest total spend, the highest spend per dosage unit, the fastest-rising prices, the highest spend per beneficiary, and the most claims. All figures are aggregate Medicare program spending, not the price any individual pays.
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
Drugs ranked by total Part D spending in 2023 — the largest lines in the program.
Highest spend per dosage unitDrugs with the highest average Medicare spending per dosage unit (pill, mL or other billing unit).
Fastest-rising pricesDrugs with the largest year-over-year increase in spending per dosage unit (2022 to 2023).
Highest spend per beneficiaryDrugs with the highest average annual Medicare Part D spending per beneficiary.
Most claimsThe drugs with the most Medicare Part D claims — the most-dispensed medicines.
Want every drug in one place? See the A–Z drug index, or browse by manufacturer.
Last updated: 2026-06-21