Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) — Medicare Part D spending
Multiple manufacturers (17) · Rank #185 by total Part D spend · CMS data year 2023
Medicare Part D spent $263,023,627 on Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) in 2023, the #185 drug by total Part D spending out of 3,598 drugs. That worked out to about $0.37 per dosage unit, $31 per claim and $123 per beneficiary, across 8,573,186 claims for 2,133,988 beneficiaries. Average spending per dosage unit rose +5.5% from 2022. These are aggregate Medicare program figures (gross drug cost), not the price you pay.
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) spending at a glance (2023)
| Metric | Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) |
|---|---|
| Total Part D spending (2023) | $263,023,627 |
| Total spending (2022) | $251,484,956 |
| Year-over-year change in total spending | +4.6% |
| Average spending per dosage unit (2023) | $0.37 |
| Change in spend per dosage unit (YoY) | +5.5% |
| Avg annual change per dosage unit (2019-2023 CAGR) | -2.5% |
| Average spending per claim (2023) | $31 |
| Average spending per beneficiary (2023) | $123 |
| Total claims (2023) | 8,573,186 |
| Beneficiaries (2023) | 2,133,988 |
| Total dosage units (2023) | 657,561,114 |
| Manufacturer(s) | Multiple manufacturers (17) |
| National rank by total spend (of 3,598 drugs) | #185 |
Source: CMS Medicare Part D Spending by Drug (data year 2023). Data as of June 2026.
2022 vs 2023
| Metric | 2022 | 2023 | Change |
|---|---|---|---|
| Total spending | $251,484,956 | $263,023,627 | +4.6% |
| Avg spend per dosage unit | $0.35 | $0.37 | +5.5% |
| Avg spend per claim | $29 | $31 | — |
| Avg spend per beneficiary | $125 | $123 | — |
| Total claims | 8,601,525 | 8,573,186 | — |
| Beneficiaries | 2,012,977 | 2,133,988 | — |
How Oxycodone-Acetaminophen compares with nearby drugs
Drugs with total Part D spending closest to Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen):
| Drug (rank) | Total spend 2023 | Per dosage unit | Per-unit YoY |
|---|---|---|---|
| Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) (this drug, #185) | $263,023,627 | $0.37 | +5.5% |
| Gammaplex (Immun Glob G(IgG)/Gly/IgA 0-50) (#183) | $265,296,669 | $20.41 | +7.6% |
| Humulin R U-500 Kwikpen (Insulin Regular, Human) (#184) | $263,635,305 | $97.23 | +1.0% |
| Nucala (Mepolizumab) (#186) | $260,986,344 | $3,769.30 | +8.8% |
| Strensiq (Asfotase Alfa) (#187) | $258,940,106 | $6,180.92 | -0.9% |
| Humira (Adalimumab) (#188) | $257,644,313 | $3,568.20 | +11.4% |
Frequently asked questions
How much does Medicare Part D spend on Oxycodone-Acetaminophen?
Medicare Part D spent $263,023,627 on Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) in 2023 (the latest CMS data year), across 8,573,186 claims for 2,133,988 beneficiaries. That ranks #185 of 3,598 drugs by total Part D spending. This is gross drug cost (Medicare, plan and beneficiary payments combined), not the price you personally pay.
What is the average spending per dosage unit for Oxycodone-Acetaminophen?
In 2023, the weighted average Medicare Part D spending per dosage unit for Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) was $0.37. Compared with 2022 it rose +5.5%. A "dosage unit" is one pill, tablet, milliliter or other billing unit, so this is not the price of a prescription.
Who makes Oxycodone-Acetaminophen?
CMS attributes Oxycodone-Acetaminophen (Oxycodone HCl/Acetaminophen) to Multiple manufacturers (17) in the 2023 Part D spending file. Average spending per claim was $31 and per beneficiary $123.
Is the Oxycodone-Acetaminophen figure the price I pay?
No. These are aggregate Medicare Part D program figures (total gross drug cost and averages across all claims), published by CMS for transparency. Your out-of-pocket cost depends on your plan, formulary, deductible and coverage phase. Always check your plan and talk to your pharmacist or doctor.
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Source & what this means
Figures are from the CMS Medicare Part D Spending by Drug dataset (data year 2023, US public domain). "Total spending" is the gross drug cost — Medicare, plan and beneficiary payments combined — for Part D claims; it is not a list price, a negotiated price, or what any individual pays. Spending per dosage unit is volume-weighted across formulations. This is general public-spending information, not medical or pricing advice. Your own cost depends on your plan, deductible and coverage phase — verify with your Part D plan and a pharmacist. Data as of June 2026. See our methodology and disclaimer.
Last updated: 2026-06-20